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CP Papers
RF Papers
Pulmonary
Oral
Parenteral
Protein
Peptide

 

CP Papers

  • Rogers, T., Gillespie, I., Hitt, J., Fransen, K., Crowl, C., Tucker, C., Kupperblatt, G., Becker, J., Wilson, D., Todd, C., Broomall, C., Evans, J., Elder, E. (2004). Development and Characterization of a Scalable Controlled Precipitation Process to Enhance the Dissolution of Poorly Water-Soluble Drugs. Pharmaceutical Research, 21 (11), 2048-2057
  • Matteucii, M., Hotze, M., Johnston, K., Williams III, W. (2006). Drug Nanoparticles by Antisolvent Precipitation: Mixing Energy versus Surfactant Stabilization. Langmuir, 22, 8951-8959
  • Matteucci, M., Brettmann, B., Rogers, T., Elder, E., Williams III, R., Johnston, K. (2007). Design of Potent Amorphous Drug Nanoparticles for Rapid Generation of Highly Supersaturated Media. Mol. Pharmaceutics, 4 (5), 782-793
  • Sinswat, P., Matteucci, M., Johnston, K., Williams III, R. (2007). Dissolution Rates and Supersaturation Behavior of Amorphous Repaglinide Particles Produced by Controlled Precipitation. J. of Biomedical Nanotechnology, 3, 18-27
  • Matteucci, M., Miller, M., Williams III, R., Johnston, K. (2008). Highly Supersaturated Solutions of Amorphous Drugs Approaching Predictions from Configurational Thermodynamic Properties. J. Phys. Chem B, 112, 16675-16681
  • Matteucci, M., Paguio, J., Miller, M., Williams III, R., Johnston, K. (2008). Flocculated Amorphous Nanoparticles for Highly Supersaturated Solutions. Pharmaceutical Research, 25 (11), 2477-2487
  • Tam, J., McConville, J., Williams III, R., Johnston, K. (2008). Amorphous Cyclosporin Nanodispersions for Enhanced Pulmonary Deposition and Dissolution. J. of Pharm. Sciences, 97 (11), 4915-4933
  • Chen, X., Matteucci, M., Lo, C., Johnston, K. (2009). Floccculation of Polymer Stabilized Nanocrystal Suspensions to Produce Redispersible Powders. Drug Dev. and Ind. Pharm., 35, 283-296
  • Matteucci, M., Paguio, J., Miller, M., Williams III, R., Johnston, K. (2009). Highly Supersaturated Solutions from Dissolution of Amorphous Itraconazole Microparticles at pH 6.8. Mol. Pharmaceutics, 6 (2), 375-385

RF Papers

  • Hu, J., Johnston, K., Williams III, R. (2004). Rapid Release Tablet Formation of Micronized Danazol Powder Produced by Spray Freezing into Liquid (SFL). J. Drug Del. Sci. Tech., 14 (4), 305-311
  • Hu, J., Johnston, K., Williams III, R. (2004). Rapid Dissolving High Potency Danazol Powders Produced by Spray Freezing into Liquid Process. Int. J. of Pharm., 271, 145-154
  • Barron, M., Young, T., Johnston, K., Williams III, R. (2003). Investigation of Processing Parameters of Spray Freezing Into Liquid to Prepare Polyethylene Glycol Polymeric Particles for Drug Delivery. AAPS Pharm. Sci. Tech. 4 (2), Article 12, 1-13
  • Hu, J., Rogers, T., Brown, J., Young, T., Johnston, K., Williams III, R. (2002) Improvement of Dissolution Rate of Poorly Water Soluble APIs Using Novel Spray Freezing into Liquid Technology. Pharmaceutical Research, 19 (9), 1278-1284
  • Hu, J., Johnston, K., Williams III, R. (2003). Spray Freezing Into Liquid (SFL) Particle Engineering Technology to Enhance Dissolution of Poorly Water Soluble Drugs: Organic Solvents versus Organic/Aqueous Co-Solvent Systems. European J. of Pharm. Sci., 20, 295-303
  • Hu, J., Johnston, K., Williams III, R. (2004). Stable Amorphous Danazol Nanostructured Powders with Rapid Dissolution Rates Produced by Spray Freezing into Liquid. Drug Dev. and Ind. Pharm., 30 (7), 695-704
  • Engstrom, J., Simpson, D., Cloonan, C., Lai, E., Williams III, R., Kitto, G., Johnston, K. (2007). Stable High Surface Area Lactate Dehydrogenase Particles Produces by Spray Freezing into Liquid Nitrogen. European J. of Pharm. And Biopharm., 65, 163-174
  • Engstrom, J., Simpson, D., Lai, E., Williams III, R., Johnston, K. (2007). Morphology of Protein Particles by Spray Freezing of Concentrated Solutions. European J. of Pharm. And Biopharm., 65, 149-162
  • Leach, W., Simpson, D., Val, T., Anuta, E., Yu, Z., Williams III, R., Johnston, K. (2004). Uniform Encapsulation of Stable Protein Nanoparticles Produced by Spray Freezing for the Reduction of Burst Release. J. Pharm. Sci., 94, 56-59
  • Rogers, T., Nelsen, A., Sarkari, M., Young, T., Johnston, K., Williams III, R. (2003). Enhanced Aqueous Dissolution of a Poorly Water Soluble Drug by Novel Particle engineering Technology: Spray-Freezing into Liquid with Atmospheric Freeze Drying. Pharm. Research, 20 (3), 485-493
  • Vaughn, J., Gao, X., Yacaman, M., Johnston, K., Williams III, R. (2005). Comparison of Powder Prodcued by Evaporative Precipitation into Aqueous Solution (EPAS) and Spray Freezing into Liquid Technologies using Novel X-contrast STEM and Complimentary Techniques. European J. of Pharm. and Biopharm., 60, 81-89
  • Yu, Z., Garcia, A., Johnston, K., William III, R. (2004). Spray Freezing into Liquid Nitrogen for Highly Stable Protein Nanostructured Particles. European J. of Pharm. and Biopharm., 58, 529-537
  • Rogers, T., Overhoff, K., Shah, P., Santiago, P., Yacaman, M., Johnston, K., Williams III, R. (2003). Micronized Powders of Poorly Water Soluble Drug Produced by a Spray-Freezing into Liquid-Emulsion Process. European J. Pharm. and Biopharm., 55, 161-172
  • Rogers, T., Hu, J., Yu, Z., Johnston, K., Williams III, R. (2002). A Novel Particle Engineering Technology: Spray Freezing into Liquid. Int. J. of Pharm., 242, 93-100
  • Rogers, T., Johnston, K. Williams III, R. (2003). Physical Stability of Micronized Powders Produced by Spray-Freezing into Liquid (SFL) to Enhance the Dissolution of an Insoluble Drug. Pharm. Dev. and Tech., 8 (2), 187-197
  • Yu, Z., Rogers, T., Hu, J., Johnston, K. Williams III, R. (2002). Preparation and Characterization of Microparticles Containing Peptide Produced by a Novel Process: Spray Freezing into Liquid. European J. of Pharm. and Biopharm., 54, 221-228
  • Yu, Z., Johnston, K., Williams III, R., (2006). Spray Freezing into Liquid versus Spray Freeze Drying: Influence of Atomization on Protein Aggregation and Biological Activity. European J. of Pharm. Sci., 27, 9-18
  • Rogers, T., Nelsen, A., Hu, J., Brown, J., Sarkari, M., Young, T., Johnston, K., Williams III, R. (2002). A Novel Particle Engineering Technology to Enhance Dissolution of Poorly Water Soluble Drugs: Spray Freezing into Liquid. European J. of Pharm. and Biopharm., 54, 271-280
  • Overhoff, K., Moreno, A., Miller, D., Johnston, K., Williams III, R. (2007). Solid Dispersions of Itraconazole and Enteric Polymers Made by Ultra-Rapid Freezing. Int. J. of Pharm., 336, 122-132
  • Purvis, T., Matteucci, M., Crisp, M., Johnston, K., Williams III, R. (2007). Rapidly Dissolving Repaglinide Powders Produced by the Ultra-Rapid Freezing Process. AAPS Pharm. Sci. Tech., 8 (3), Article 58, E1-E9
  • Overhoff, K., McConville, J., Yang, W., Johnston, K., Peters, J., Williams III, R. (2007). Effect of Stabilizer on the Maximum Degree and Extent of Supersaturation and Oral Absorption of Tacrolimus Made by Ultra-Rapid Freezing. Pharm. Research, 25 (1), 167-175
  • Sinswat, P., Overhoff, K., McConville, J., Johnston, K., Williams III, R. (2008). Nebulization of Nanoparticulate Amorphous or Crystalline Tacrolimus – Single-Dose Pharmacokinetics Study in Mice. European J. of Pharm. and Biopharm., 69, 1057-1066
  • Engstrom, J., Lai, E., Ludher, B., Chen, B., Milner, T., Williams III, R., Kitto, G., Johnston, K. (2008). Formation of Stable Submicron Protein Particles by Thin Film Freezing. Pharm. Research, 25 (6), 1334-1346
  • Engstrom, J., Tam, J., Miller, M., Williams III, R., Johnston, K. (2008). Templated Open Flocs of Nanorods for Enhanced Pulmonary Delivery with Pressurized Metered Dose Inhalers. Pharm. Research, 26 (1), 101-117
  • Overhoff, K., Engstrom, J., Chen, B., Scherzer, B., Milner, T., Johnston, K., Williams III, R. (2007). Novel Ultra-Rapid Freezing Particle Engineering Process for Enhancement of Dissolution Rates of Poorly Water-Soluble Drugs. European J. of Pharm. and Biopharm., 65, 57-67
  • DiNunzio, J., Miller, D., Yang, W., McGinity, J., Williams III, R. (2008). Amorphous Composition Using Concentration Enhancing Polymers for Improved Bioavailability of Itraconazole. Mol. Pharm., 5 (6), 968-980
  • Yang, W., Tam, J., Miller, D., Zhou, J., McConville, J., Johnston, K., Williams III, R. (2008). High Bioavailability from Nebulized Itraconazole Nanoparticle Dispersions with Biocompatible Stabilizers. Int. J. of Pharm., 361, 177-188

Pulmonary

  • Matteucii, M., Hotze, M., Johnston, K., Williams III, W. (2006). Drug Nanoparticles by Antisolvent Precipitation: Mixing Energy versus Surfactant Stabilization. Langmuir, 22, 8951-8959
  • Tam, J., McConville, J., Williams III, R., Johnston, K. (2008). Amorphous Cyclosporin Nanodispersions for Enhanced Pulmonary Deposition and Dissolution. J. of Pharm. Sciences, 97 (11), 4915-4933
  • Barron, M., Young, T., Johnston, K., Williams III, R. (2003). Investigation of Processing Parameters of Spray Freezing Into Liquid to Prepare Polyethylene Glycol Polymeric Particles for Drug Delivery. AAPS Pharm. Sci. Tech. 4 (2), Article 12, 1-13
  • Sinswat, P., Overhoff, K., McConville, J., Johnston, K., Williams III, R. (2008). Nebulization of Nanoparticulate Amorphous or Crystalline Tacrolimus – Single-Dose Pharmacokinetics Study in Mice. European J. of Pharm. and Biopharm., 69, 1057-1066
  • Engstrom, J., Lai, E., Ludher, B., Chen, B., Milner, T., Williams III, R., Kitto, G., Johnston, K. (2008). Formation of Stable Submicron Protein Particles by Thin Film Freezing. Pharm. Research, 25 (6), 1334-1346
  • Engstrom, J., Tam, J., Miller, M., Williams III, R., Johnston, K. (2008). Templated Open Flocs of Nanorods for Enhanced Pulmonary Delivery with Pressurized Metered Dose Inhalers. Pharm. Research, 26 (1), 101-117
  • Yang, W., Tam, J., Miller, D., Zhou, J., McConville, J., Johnston, K., Williams III, R. (2008). High Bioavailability from Nebulized Itraconazole Nanoparticle Dispersions with Biocompatible Stabilizers. Int. J. of Pharm., 361, 177-188

Oral

  • Rogers, T., Gillespie, I., Hitt, J., Fransen, K., Crowl, C., Tucker, C., Kupperblatt, G., Becker, J., Wilson, D., Todd, C., Broomall, C., Evans, J., Elder, E. (2004). Development and Characterization of a Scalable Controlled Precipitation Process to Enhance the Dissolution of Poorly Water-Soluble Drugs. Pharmaceutical Research, 21 (11), 2048-2057
  • Matteucci, M., Brettmann, B., Rogers, T., Elder, E., Williams III, R., Johnston, K. (2007). Design of Potent Amorphous Drug Nanoparticles for Rapid Generation of Highly Supersaturated Media. Mol. Pharmaceutics, 4 (5), 782-793
  • Sinswat, P., Matteucci, M., Johnston, K., Williams III, R. (2007). Dissolution Rates and Supersaturation Behavior of Amorphous Repaglinide Particles Produced by Controlled Precipitation. J. of Biomedical Nanotechnology, 3, 18-27
  • Matteucci, M., Miller, M., Williams III, R., Johnston, K. (2008). Highly Supersaturated Solutions of Amorphous Drugs Approaching Predictions from Configurational Thermodynamic Properties. J. Phys. Chem B, 112, 16675-16681
  • Matteucci, M., Paguio, J., Miller, M., Williams III, R., Johnston, K. (2008). Flocculated Amorphous Nanoparticles for Highly Supersaturated Solutions. Pharmaceutical Research, 25 (11), 2477-2487
  • Chen, X., Matteucci, M., Lo, C., Johnston, K. (2009). Floccculation of Polymer Stabilized Nanocrystal Suspensions to Produce Redispersible Powders. Drug Dev. and Ind. Pharm., 35, 283-296
  • Matteucci, M., Paguio, J., Miller, M., Williams III, R., Johnston, K. (2009). Highly Supersaturated Solutions from Dissolution of Amorphous Itraconazole Microparticles at pH 6.8. Mol. Pharmaceutics, 6 (2), 375-385
  • Hu, J., Johnston, K., Williams III, R. (2004). Rapid Release Tablet Formation of Micronized Danazol Powder Produced by Spray Freezing into Liquid (SFL). J. Drug Del. Sci. Tech., 14 (4), 305-311
  • Hu, J., Johnston, K., Williams III, R. (2004). Rapid Dissolving High Potency Danazol Powders Produced by Spray Freezing into Liquid Process. Int. J. of Pharm., 271, 145-154
  • Hu, J., Rogers, T., Brown, J., Young, T., Johnston, K., Williams III, R. (2002) Improvement of Dissolution Rate of Poorly Water Soluble APIs Using Novel Spray Freezing into Liquid Technology. Pharmaceutical Research, 19 (9), 1278-1284
  • Hu, J., Johnston, K., Williams III, R. (2003). Spray Freezing Into Liquid (SFL) Particle Engineering Technology to Enhance Dissolution of Poorly Water Soluble Drugs: Organic Solvents versus Organic/Aqueous Co-Solvent Systems. European J. of Pharm. Sci., 20, 295-303
  • Hu, J., Johnston, K., Williams III, R. (2004). Stable Amorphous Danazol Nanostructured Powders with Rapid Dissolution Rates Produced by Spray Freezing into Liquid. Drug Dev. and Ind. Pharm., 30 (7), 695-704
  • DiNunzio, J., Miller, D., Yang, W., McGinity, J., Williams III, R. (2008). Amorphous Composition Using Concentration Enhancing Polymers for Improved Bioavailability of Itraconazole. Mol. Pharm., 5 (6), 968-980
  • Rogers, T., Overhoff, K., Shah, P., Santiago, P., Yacaman, M., Johnston, K., Williams III, R. (2003). Micronized Powders of Poorly Water Soluble Drug Produced by a Spray-Freezing into Liquid-Emulsion Process. European J. Pharm. and Biopharm., 55, 161-172
  • Rogers, T., Hu, J., Yu, Z., Johnston, K., Williams III, R. (2002). A Novel Particle Engineering Technology: Spray Freezing into Liquid. Int. J. of Pharm., 242, 93-100
  • Rogers, T., Johnston, K. Williams III, R. (2003). Physical Stability of Micronized Powders Produced by Spray-Freezing into Liquid (SFL) to Enhance the Dissolution of an Insoluble Drug. Pharm. Dev. and Tech., 8 (2), 187-197
  • Vaughn, J., Gao, X., Yacaman, M., Johnston, K., Williams III, R. (2005). Comparison of Powder Prodcued by Evaporative Precipitation inot Aqueous Solution (EPAS) and Spray Freezing into Liquid Technologies using Novel X-contrast STEM and Complimentary Techniques. European J. of Pharm. and Biopharm., 60, 81-89
  • Overhoff, K., Engstrom, J., Chen, B., Scherzer, B., Milner, T., Johnston, K., Williams III, R. (2007). Novel Ultra-Rapid Freezing Particle Engineering Process for Enhancement of Dissolution Rates of Poorly Water-Soluble Drugs. European J. of Pharm. and Biopharm., 65, 57-67
  • Rogers, T., Nelsen, A., Sarkari, M., Young, T., Johnston, K., Williams III, R. (2003). Enhanced Aqueous Dissolution of a Poorly Water Soluble Drug by Novel Particle engineering Technology: Spray-Freezing into Liquid with Atmospheric Freeze Drying. Pharm. Research, 20 (3), 485-493
  • Rogers, T., Nelsen, A., Hu, J., Brown, J., Sarkari, M., Young, T., Johnston, K., Williams III, R. (2002). A Novel Particle Engineering Technology to Enhance Dissolution of Poorly Water Soluble Drugs: Spray Freezing into Liquid. European J. of Pharm. and Biopharm., 54, 271-280
  • Overhoff, K., Moreno, A., Miller, D., Johnston, K., Williams III, R. (2007). Solid Dispersions of Itraconazole and Enteric Polymers Made by Ultra-Rapid Freezing. Int. J. of Pharm., 336, 122-132
  • Purvis, T., Matteucci, M., Crisp, M., Johnston, K., Williams III, R. (2007). Rapidly Dissolving Repaglinide Powders Produced by the Ultra-Rapid Freezing Process. AAPS Pharm. Sci. Tech., 8 (3), Article 58, E1-E9
  • Overhoff, K., McConville, J., Yang, W., Johnston, K., Peters, J., Williams III, R. (2007). Effect of Stabilizer on the Maximum Degree and Extent of Supersaturation and Oral Absorption of Tacrolimus Made by Ultra-Rapid Freezing. Pharm. Research, 25 (1), 167-175
  • Barron, M., Young, T., Johnston, K., Williams III, R. (2003). Investigation of Processing Parameters of Spray Freezing Into Liquid to Prepare Polyethylene Glycol Polymeric Particles for Drug Delivery. AAPS Pharm. Sci. Tech. 4 (2), Article 12, 1-13

Parenteral

  • Engstrom, J., Lai, E., Ludher, B., Chen, B., Milner, T., Williams III, R., Kitto, G., Johnston, K. (2008). Formation of Stable Submicron Protein Particles by Thin Film Freezing. Pharm. Research, 25 (6), 1334-1346

Protein

  • Engstrom, J., Simpson, D., Cloonan, C., Lai, E., Williams III, R., Kitto, G., Johnston, K. (2007). Stable High Surface Area Lactate Dehydrogenase Particles Produces by Spray Freezing into Liquid Nitrogen. European J. of Pharm. And Biopharm., 65, 163-174
  • Engstrom, J., Simpson, D., Lai, E., Williams III, R., Johnston, K. (2007). Morphology of Protein Particles by Spray Freezing of Concentrated Solutions. European J. of Pharm. And Biopharm., 65, 149-162
  • Leach, W., Simpson, D., Val, T., Anuta, E., Yu, Z., Williams III, R., Johnston, K. (2004). Uniform Encapsulation of Stable Protein Nanoparticles Produced by Spray Freezing for the Reduction of Burst Release. J. Pharm. Sci., 94, 56-59
  • Yu, Z., Garcia, A., Johnston, K., William III, R. (2004). Spray Freezing into Liquid Nitrogen for Highly Stable Protein Nanostructured Particles. European J. of Pharm. and Biopharm., 58, 529-537
  • Yu, Z., Johnston, K., Williams III, R., (2006). Spray Freezing into Liquid versus Spray Freeze Drying: Influence of Atomization on Protein Aggregation and Biological Activity. European J. of Pharm. Sci., 27, 9-18
  • Engstrom, J., Lai, E., Ludher, B., Chen, B., Milner, T., Williams III, R., Kitto, G., Johnston, K. (2008). Formation of Stable Submicron Protein Particles by Thin Film Freezing. Pharm. Research, 25 (6), 1334-1346
  • Engstrom, J., Tam, J., Miller, M., Williams III, R., Johnston, K. (2008). Templated Open Flocs of Nanorods for Enhanced Pulmonary Delivery with Pressurized Metered Dose Inhalers. Pharm. Research, 26 (1), 101-117

Peptide

  • Yu, Z., Rogers, T., Hu, J., Johnston, K. Williams III, R. (2002). Preparation and Characterization of Microparticles Containing Peptide Produced by a Novel Process: Spray Freezing into Liquid. European J. of Pharm. and Biopharm., 54, 221-228

 

 

 
 

 

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